Chronic stress induced changes in locus coeruleus neuronal activity

PAVCOVICH, L.; CANCELA, L.M.; VOLOSIN, M.; MOLINA VICTOR ALEJANDRO; RAMIREZ, O.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1990 vol. 24 p. 293 - 293

p class="marginB3" align="justify">Locus coeruleus (LC) activity was assessed in rats exposed to either acute or chronic stress. After one immobilization session, the number of spontaneously active LC neurons dramatically decreased. On the other hand, repeated restraint sessions enhanced noradrenergic (NA) transmission and the inhibitory effect of clonidine (CLON) was greater on these cells than in those of controls. These results bear on the adaptive changes in the NA system following acute or chronic stress.