Effect of chronic variables stress on monoamine receptors: influence of imipramine administration.

MOLINA VICTOR ALEJANDRO; VOLOSIN, M.; CANCELA, L.M.; KELLER, E.; MURUA, S.; BASSO, A.M.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1990 vol. 35 p. 335 - 335

p class="marginB3" align="justify">Adult male rats were exposed to a series of unpredictable stressors, a paradigm considered to be a model of experimental depression, with or without concurrent administration of imipramine. One day after the last stress event of the chronic regime, binding of cortical beta-adrenoreceptors and the behavioral serotonin (5-HT) syndrome induced by 5-methoxy-N,N,dimethyltryptamine (5-MeODMT) were determined in all the experimental groups. Stressed rats showed an ´up-regulation´ of cortical beta-adrenergic sites, while similar values to control rats were observed when stressed animals were administered imipramine. Regarding the behavioral 5-HT syndrome, comparable behavioral scores were observed between controls and chronically stressed rats. The combination of chronic exposure to different stressors with imipramine treatment resulted in a significant increase of forepaw treading and Straub tail scores. The probable facilitation of behavioral deficits indu