Facilitating influence of stress on the consolidation of fear memory induced by a weak training. reversal by midazolam pretreatment

MALDONADO NOELIA; MARTIJENA IRENE .D.; MOLINA VICTOR ALEJANDRO

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2011 vol. 225 p. 77 - 77

font size="1" face="GulliverRM"> It is well known that an emotionally arousing experience usually results in a robust and persistent memory trace. The present study explored the potential mechanisms involved in the influence of stress on the consolidation of a contextual fear memory in animals subjected to a weak fear training protocol, and whether pretreatment with intra-basolateral amygdala or systemic administration of midazolam (MDZ) prevents the potential stress-induced influence on fear memory formation. A previous restraint session facilitated fear retention, this effect was not due to a sensitized effect of restraint on the footshock experience. MDZ, both systemically or intra-basolateral amygdala infusion prior to the restraint, attenuated the stress-induced promoting influence on f