Involvement of septal cdk5 in the emergence of excessive anxiety induced by stress

BIGNANTE, E.A.; RODRIGUEZ MANZANARES , P.; MLEWSKI, E.C.; BERTOTTO M.E.; BUSSOLINO, D.F. ; PAGLINI, G.; VICTOR A. MOLINA

Elsevier

Año: 2008 vol. 18 p. 578 - 578

font size="1" face="AdvTTae86113c"> The aim of the present study was to evaluate whether the activation of Cdk5, a protein that has been suggested to participate in higher cognitive functions, is required for the onset of a sensitized anxiety-related behavior induced by stress. The exposure to restraint enhanced both Cdk5 expression in certain subareas of the septohippocampal system, principally in the lateral septum (LS) and septal Cdk5 kinase activity in rats. Behaviorally, restrained wild type mice showed a behavior indicative of enhanced anxiety in the elevated plus maze (EPM). In contrast, unstressed mice and stressed knockout mice, which lacked the p35 protein, the natural activator of Cdk5, displayed similar anxiety-like behavior in the EPM. Finally, the intra-LS infusion of olomoucine