Involvement of the Lateral Septum and the Ventral Hippocampus in the emotional sequelae induced by social defeat: role of glucocorticoid receptors

CALFA, G; BUSSOLINO, D.; AND MOLINA, V.A.

Elsevier

Año: 2007 vol. 181 p. 23 - 23

b> Abstract An important area of the brain aversive circuitry is the lateral septum (LS), together with its principal connections to diverse Hippocampal regions. The aim of this work was to evaluate whether the LS-Hippocampus network participates in the increased anxiety-like behavior produced by a previous defeat experience. The neural activation of different regions of the Hippocampus was assessed by the number of Fos positive cells in animals previously defeated. A notable elevation in the expression of this protein was observed in CA1, CA2, CA3, and Dentate Gyrus, for both dorsal and ventral Hippocampus. The local administration of a glucocorticoid receptor (GR or type II) antagonist, but not of a mineralcorticoid receptor (MR or type II) antagonist, into the LS b