Resumen:
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Abstract?The current research examines the influence of
midazolam (MDZ) on memory reconsolidation using a contextual
fear paradigm in rats, based on three context-shock
training trials (0.7 mA, 3 s). First, we evaluate the effect of
MDZ (1 mg/kg, i.p.) injected shortly after the training procedure.
Second, we examined the influence of MDZ after a brief
exposure (90 s) either in the training context (reactivation
procedure) or in a neutral environment (no reactivation procedure)
and one day later, freezing behavior was scored
when rats were re-exposed to the training environment.
Third, we investigate both the effect of MDZ administered at
different times following reactivation on fear mem