Glucocorticoids receptors in Lateral Septum are involved in the modulation of the emotional sequelae induced by social defeat.

CALFA, GASTON; VOLOSIN, MARTA AND VICTOR A. MOLINA

Elsevier

Año: 2006 vol. 172 p. 324 - 324

b> Abstract The current research studied the behavior adopted in the elevated plus maze (EPM) of rats previously subjected to a social defeat using the resident-intruder paradigm. One day after defeat, intruder animals exhibited an anxiogenic-like behavior in the EPM. In addition, we also evaluated the role of the corticosteroid receptor system (minerlocorticoid ? MR ? and glucocorticoid ? GR ? receptors) from the lateral septum (LS) on the anxiety generated by social defeat. The LS is an area of the aversive circuitry that is preferentially activated in passive defensive postures, and participates ? together with other brain areas ? in the modulation of aversive states. Intruder animals were infused into the LS with the MR or GR antagonist (ZK 91587 and RU 38486, res