Influence of ethanol withdrawal on fear memory: effect of d-cycloserine

BERTOTTO, M.E.; BUSTOS, S.G.; MOLINA, V.A. AND MARTIJENA I.D

Elsevier

Año: 2006 vol. 142 p. 979 - 979

b> Abstract?Animals made dependent via an ethanol (ETOH) -containing liquid diet (6% v/v) for 14 days were subjected to a contextual fear conditioning paradigm 3 days after the last consumption day. After conditioning, rats were subjected to four extinction trials by exposing the animals to the conditioned context and their freezing was evaluated for each trial. Immediately after the first extinction trial, animals were injected with D-cycloserine (DCS) 5 mg/kg i.p., a dose that did not influence the extinction in control rats. Spontaneous recovery of learned fear was tested seven days after the last extinction trial. The following day, animals were subje