Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain.

BARROS VG, BERGER MA, MARTIJENA ID, SARCHI MI, PEREZ AA, MOLINA VA, TARAZI FL, ANTONELLI MC.

Wiley Interscience

Lugar: Nueva York, EE.UU; Año: 2004 vol. 76 p. 488 - 488

tressful stimuli during pregnancy induce complex effects that influence the development of offspring. These effects can be prevented by environmental manipulations during the early postnatal period. Repeated restraint during the last week of pregnancy was used as a model of prenatal stress, and adoption at birth was used to change the postnatal environment. No differences were found in various physical landmarks, except for testis descent, for which all prenatally stressed pups showed a 1-day delay in comparison with control rats, regardless of the postnatal adoption procedure. Levels of dopamine (DA) D(2) and glutamate (Glu) N-methyl-D-aspartate (NMDA) receptors were differentially regulated in different forebrain regions of cross-fostered adult offspring. Increased concentrations of cortical D(2) receptors detected in stressed pups, raised by a gestationally stressed biological mother, were not detected when the pups were raised by a control mother. Control pups raised by a foster m