The Effect of Midazolam and Propranolol on Fear Memory Reconsolidation in Ethanol-Withdrawn Rats: Influence of D-Cycloserine

CAMBRIDGE UNIV PRESS

Lugar: Cambridge; Año: 2015 vol. 18 p. 1 - 1

ithdrawal from chronic ethanol facilitates the formation of contextual fear memory and delays the onsetto extinction, with its retrieval promoting an increase in ethanol consumption. Consequently, manipulations aimed toreduce these aversive memories, may be beneficial in the treatment of alcohol discontinuation symptoms. Related to this,pharmacological memory reconsolidation blockade has received greater attention due to its therapeutic potential.Methods: Here, we examined the effect of post-reactivation amnestic treatments such as Midazolam (MDZ, 3 mg/kg i.p) andPropranolol (PROP, 5 mg/kg i.p) on contextual fear memory reconsolidation in ethanol- withdrawn (ETOH) rats. Next, we examinedwhether the activation of N-methyl-D-aspartate (NMDA) receptors induced by d-cycloserine (DCS, 5 mg/kg i.p., a NMDA partialagonist) before memory reactivation can facilitate the disruptive effect of PROP and MDZ on fear memory in ETOH rats.Results: We observed a resistance to the disruptive effect of b