. Stress-induced resistance to the fear memory labilization/reconsolidation process. Involvement of the Basolateral Amygdala Complex.

MOLINA VICTOR ALEJANDRO

NEUROPHARMACOLOGY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2016 vol. 109 p. 349 - 349

0028-3908

onsolidated memories can enter into a labile state after reactivation followed by a restabilizationprocess defined as reconsolidation. This process can be interfered with Midazolam (MDZ), a positiveallosteric modulator of the GABA-A receptor. The present study has evaluated the influence of prior stresson MDZ?s interfering effect. We also assessed the influence of both systemic and intra-basolateralamygdala (BLA) infusion of D-cycloserine (DCS), a partial agonist of the NMDA receptors, on the MDZeffect in previously stressed rats. Furthermore, we analyzed the effect of stress on the expression of Zif-268 and the GluN2B sites, two molecular markers of the labilization/reconsolidation process, followingreactivation. The results revealed that prior stress resulted into a memory trace that was insensitive tothe MDZ impairing effect. Both systemic and intra-BLA DCS administration previous to reactivationrestored MDZ?s disruptive effect on memory reconsolidation in stressed animals. Further