GABAergic signaling within the Basolateral Amygdala Complex modulates resistance to the labilization/reconsolidation process

MOLINA VICTOR ALEJANDRO

NEUROBIOLOGY OF LEARNING AND MEMORY

ACADEMIC PRESS INC ELSEVIER SCIENCE

Lugar: Amsterdam; Año: 2017 vol. 144 p. 166 - 166

1074-7427

t is well known that stress can affect mnemonic processes. In particular, stress before contextual fearconditioning induces a memory which exhibits resistance to being interfered with by Midazolam(MDZ) when applied after memory retrieval. Moreover, stress exposure strongly affects GABAergic transmissionwithin the Basolateral Amygdala Complex (BLA), a brain structure critically involved in fearmemory processing. The present study evaluated the involvement of GABAergic signaling within theBLA on the induction of resistance to memory reconsolidation interference. Results showed that MDZadministered intra-BLA before stress prevented the induction of resistance to the interfering effect of systemicadministration of both MDZ and Propranolol on fear memory reconsolidation, when both appliedafter memory retrieval. The blockade of amygdala GABA-A receptors by the antagonist Bicuculline (BIC)before memory encoding induced resistance to interference by post-recall MDZ administration, similarlyto