Effect of a positive reinforcing stimulus on fear memory reconsolidation in etanol withdrawn rats: Influence of D-Cycloserine.

ORTIZ VANESA

BEHAVIOURAL BRAIN RESEARCH

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 315 p. 56 - 56

0166-4328

he pharmacological blockade of memory reconsolidation has been suggested as a potential treatmentto the attenuation of maladaptive memories associated to psychiatric disorders and drug addiction. Tointerfere with the process of fear memory reconsolidation using a manipulation safer than pharmacologicalinterventions, here we examined whether a positive reinforcing stimulus (non-alcoholic beer,NB) post-memory retrieval can decrease the fear response in ethanol withdrawn (ETOH) animals. Wefirst evaluated the potential interfering effect of NB on memory reconsolidation in non-ethanol dependent(control, CON) rats. Non-alcoholic beer intake shortly after memory retrieval attenuated the fearresponse in CON rats. A resistance to destabilization/reconsolidation process was previously observed inETOH rats, which was reversed by the activation of NMDA receptor induced by pre-retrieval d-cycloserine(DCS) administration. Therefore, the influence of DCS (5 mg/kg; i.p.) to facilitate the disruptive