Ethanol withdrawal limits fear memory reactivation-induced molecular events associated with destabilization phase: Influence of D-cycloserine

MOLINA VICTOR ALEJANDRO

PROGRESS OF NEUROPSYCHOPHARMACOLOGY AND BIOLOGICAL PSYCHIATRY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2019

0278-5846

1-day fear memory in ethanol withdrawn (ETOH) rats is resistant to destabilization-reconsolidation process.However, D-cycloserine (DCS) reverts this disturbance. Considering that the formation of pathological fear memories in humans often occurs long time before the requirement of an intervention, the study of older memories is relevant in ETOH rats. In addition, the resistance to destabilization and DCS effect on this memory phase at molecular level in ETOH rats have not been corroborated yet. Firstly, we examined the effect of a pharmacological intervention after reactivation on reconsolidation of a 7-day fear memory in ETOH rats. Then,and considering that enhanced GluN2B expression and ubiquitin-proteasome system (UPS) activity are involved in destabilization, we evaluated them following reactivation in ETOH rats. Furthermore, DCS effect on suchdestabilization markers was examined. It was found that the pharmacological intervention after reactivation did not affect the 7-day fear