Resistance to fear memory destabilization triggers exaggerated emotionallike responses following memory reactivation

MOLINA VICTOR ALEJANDRO

PROGRESS OF NEUROPSYCHOPHARMACOLOGY AND BIOLOGICAL PSYCHIATRY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2019

0278-5846

ear memory reactivation does not always lead to memory destabilization-reconsolidation. For instance, fearmemories formed following withdrawal from chronic ethanol consumption or a stressful event are less likely tobecome destabilized after reactivation, with the effect of recall of these memories on the affective state stillrequiring elucidation. Here, we investigated the negative emotional-like responses following fear memory reactivation in ethanol-withdrawn (ETOH) rats by focusing on the possible role played by destabilization. Ourfindings indicated that ETOH rats displayed an increased freezing in a novel context and an anxiogenic-likeresponse in the elevated plus maze (EPM) following memory reactivation, whereas the behavior of CON animalswas not affected. The destabilization blockade by pre-reactivation nimodipine (16 mg/kg, s.c) administration promoted in CON animals a similar behavior in the EPM and in a novel environment as that exhibited by ETOH rats after the reminder. Mor