Antibodies which block anti-myelin basic protein antibodies associated with development of experimental autoimmune encephalomyelitis (EAE) in wistar rats

VILCAES AA; DEGANO AL; LOPEZ PHH; NORES GA; ROTH GA

JOURNAL OF NEUROIMMUNOLOGY

Año: 2005 vol. 164 p. 31 - 31

0165-5728

font face="AdvTTf90d833a.I" size="1"> Objective: In sera from normal rats and from rats injected with whole myelin in complete Freund adjuvant to induce EAE we study the presence of antibodies capable to inhibit the reactivity of autoantibodies directed to myelin basic protein (MBP).In sera from normal rats and from rats injected with whole myelin in complete Freund adjuvant to induce EAE we study the presence of antibodies capable to inhibit the reactivity of autoantibodies directed to myelin basic protein (MBP). Methods: Sera from rats that developed or not clinical signs of EAE were obtained previously to immunization, at acute stage of the disease and when the animals were completely recuperated, and chromatographied on a protein G-Sepharose column to obtain the retained (