Unusual presence of anti-GM1 IgG-antibodies in a healthy individual, and their possible involvement in the origin of disease-associated anti-GM1 antibodies

LARDONE RD; ALANIZ ME; IRAZOQUI FJ; NORES GA

JOURNAL OF NEUROIMMUNOLOGY

Año: 2006 vol. 173 p. 174 - 174

0165-5728

p class="Textodenotaalfinal" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 200%; mso-pagination: widow-orphan; tab-stops: 28.8pt 57.6pt; mso-hyphenate: none">Anti-GM1 antibodies of the IgG isotype are found in serum from patients with Guillain-Barré syndrome. In normal human sera, anti-GM1 IgM-antibodies are commonly present, but their IgG counterpart has not been previously demonstrated. During routine screening, we found a normal human serum with a high titer of anti-GM1 IgG-antibodies (IgG1 subclass). Affinity estimation by soluble antigen binding inhibition indicated that they are low-affinity antibodies with IC50 values between one and two orders of magnitude higher than those of anti-GM1 IgG-antibodies from Guillain-Barré patients. Various antibody parameters remained fairly constant during one year, in additional serum samples taken at 4-month intervals. Such anti-GM