Validation of a rabbit model of neuropathy induced by immunization with gangliosides

MOYANO, AL; COMÍN R; LARDONE RD; ALANIZ ME; IRAZOQUI FJ,; NORES GA

Elsevier

Lugar: Amsterdan; Año: 2008 vol. 272 p. 110 - 110

h1 style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 1cm; LINE-HEIGHT: 200%">The induction of neurological signs by immunization of rabbits with gangliosides has been a controversial topic for many years. Recently, Yuki et al. (Ann. Neurol. 2001, 49, 712) described an immunization protocol, including keyhole lympet hemocyanin in addition to ganglioside, that induced a neurological disease resembling human Guillain-Barré syndrome. We employed this protocol in our laboratory and succeeded in reproducing the disease. Five different experiments were performed during a period of two years by different operators, using different batches of drugs, in a total of 26 rabbits. Despite minor variations in onset time and severity of the induced disease, the model proved to be reproducible. Both gangliosides and keyhole