In vivo immunomodulatory effects of the lectin from edible mushroom Agaricus bisporus

IRAZOQUI FJ

Food & Function

Royal Society of Chemistry

Lugar: London; Año: 2016 vol. 7 p. 269 - 269

2042-6496

ectins are glycan-binding proteins present in mushroom, seeds and fruits. They are resistant to digestion in the gastrointestinal tract and enter intact to the circulation. The aim of this study was to evaluate the effect of Agaricus bisporus lectin (ABL) on modulation of immune responses analyzing the physiological repercussion of this food protein. Here was studied the influence of ABL on innate and adaptive immune response as well as its effect in two different pathologies that involve the immune system. ABL inhibited in vitro nitric oxide production by mouse peritoneal macrophages in response to the pro-inflammatory stimuli lipopolysaccharide but no modify the activity of arginase showing that while ABL downregulates M1 activation it does not affect M2 activation. A dose dependent inhibition of cell proliferation was observed in the presence of ABL when mononuclear cells were cultured in the presence of the mitogen Con A as well as in mixed lymphocytes assays. The in vivo influen