The immune response to Thomsen-Friedenreich disaccharide, and glycan engineering (review por invitación)

IRAZOQUI FJ; SENDRA VG; LARDONE RD; NORES GA

IMMUNOLOGY AND CELL BIOLOGY

Año: 2005 vol. 83 p. 405 - 405

0818-9641

b> Cancer-associated mucins show frequent alterations of their oligosaccharide chain profile, with a switch to unmask normally cryptic O-glycan backbone and core regions. Epithelial tumour cells typically show overexpression of the uncovered Gal a 1-3GalNAc b-O-Ser/Thr (Core 1) structure, known as the T antigen or the Thomsen?Friedenreich antigen, the oligosaccharide chain of which is called the Thomsen?Friedenreich disaccharide (TFD). T antigen expression has been associated with immunosuppression, metastasis dissemination, and the proliferation of cancer cells. Several different strategies have been used to trigger a specific immune response to TFD. Natu