Hemin induces autophagy in a leukemic erythroblast cell line through the LRP1 receptor

GROSSO, RUBEN ADRIAN; CALDARONE, PAULA VIRGINIA SUBIRADA; SÁNCHEZ, MARÍA CECILIA; CHIABRANDO, GUSTAVO ALBERTO; COLOMBO, MA?IA ISABEL; FADER, CLAUDIO MARCELO

BIOSCIENCE REPORTS

PORTLAND PRESS LTD

Año: 2019 vol. 39

0144-8463

emin is an erythropoietic inductor capable of inducing autophagy in erythroid-like cell lines. Low-density lipoprotein receptor-related protein 1 (LRP1) is a transmembrane receptor involved in a wide range of cellular processes, such as proliferation, differentiation, and metabolism. Our aim was to evaluate whether LRP1 is responsible for hemin activity in K562 cells, with the results demonstrating a three-fold increase in LRP1 gene expression levels (P-values