Effect of retinal laser photocoagulation on the activity of metalloproteinases and the á2-macroglobulin proteolytic state in the vitreous of eyes with proliferative diabetic retinopathaty

SÁNCHEZ MC; LUNA JD; BARCELONA PF; GRAMAJO AL; JUAREZ PC; RIERA CM; CHIABRANDO GA

EXPERIMENTAL EYE RESEARCH

ELSEVIER

Año: 2007 vol. 85 p. 644 - 644

0014-4835

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 200%; TEXT-ALIGN: justify; mso-layout-grid-align: none">Panretinal photocoagulation (PRP) reduces the incidence of severe visual loss in proliferative diabetic retinopathy (PDR). The aim of the study was to determine the effect of PRP on the activity of matrix metalloproteinase-2 (MMP-2) and MMP-9, and also on the á2-Macroglobulin (á2M) proteolytic state in the vitreous of eyes with PDR. Vitreous samples were obtained from patients undergoing vitrectomy for the treatment of retinal diseases: 17 with PDR and 8 with idiopathic macular hole (MH). Qualitative