GM1 ganglioside enhances the rewarding properties of cocaine in rats

VALDOMERO A, HANSEN C, GEREZ DE BURGOS N, CUADRA GR, ORSINGHER OA.

ELSEVIER SCIENCE BV

Año: 2010 vol. 630 p. 79 - 79

M1 pretreatment enhanced the rewarding properties of cocaine as assessed in the conditioned place preference paradigm. This effectwas shown by the lower dosage of cocaine necessary to induce conditioning comparedwith rats receiving cocaine alone, aswell as by the fewernumber of sessions necessary to induce place preference.GM1 pretreatment did not modify the plasma level of cocaine, but it induced a significant increase in the brain cocaine level compared with animals receiving cocaine alone. In order to evaluate the possibility that GM1 pretreatment may alter the pharmacokinetic parameters of cocaine, the brain and plasma esterase activities, the plasma bound/free cocaine ratio and the brain blood barrier permeability to i.v. Evans Blue administration were assessed. None of these parameters was modified by the GM1 administration. In addition, GM1 (100 μM) did not alter the dopamine transporter inhibition induced by cocaine (10−7?10−5 M), as determined by the uptake