Perinatal protein deprivation facilitates morphine cross-sensitization to cocaine and enhances ∆FosB expression in adult rats.

PERONDI MC.; GUTIERREZ MC.; VALDOMERO A.; CUADRA GR.

BEHAVIOURAL BRAIN RESEARCH

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2017 vol. 333 p. 203 - 203

0166-4328

revious studies have indicated that neural changes induced by early nutritional insult cause an altered response to pharmacological treatments, including addictive drugs. This study evaluates the influence of perinatal protein malnutrition in developing cross-sensitization to cocaine-induced rewarding effects in animals pre-exposed to morphine.Different groups of well-nourished (C-rats) and protein-deprived animals (D-rats) were treated twice a day for three days with increasing doses of morphine or with saline. After 3 days, the incentive motivational effects of cocaine were assessed in a Conditioned Place Preference paradigm in both groups.In saline pre-treated animals, dose-response curves to cocaine revealed a conditioning effect in D-rats at doses of 5, 7.5 and 10 mg/kg, while this effect was observed in C-rats only with 10 and 15 mg/kg. Furthermore, when animals of both groups were pre-treated with escalating doses of morphine, cross-sensitization to the conditioning effect of c