c-Fos and phosphatidylinositol-4,5-bisphosphate reciprocally reorganize in mixed monolayers.

GRACIELA A BORIOLI; BEATRIZ LEONOR CAPUTTO; BRUNO MAGGIO,

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2005 vol. 1668 p. 41 - 41

p class="MsoNormal" style="MARGIN: 0pt; mso-layout-grid-align: none">Abstract The transcription factor c-Fos has surface thermodynamic properties that allow it to differentially interact with phospholipids, especially PIP2. It regulates phospholipid metabolism both in vivo and in vitro, and modulates degradation of phospholipid monolayers by phospholipases in a way that depends on the membrane intermolecular packing (i.e., surface lateral pressure). With the aim to understand details of the interactions of c-Fos at the membrane level, we studied the surface packing, dipole potential, compressibility and topography of mixed films of the