c-Fos associates with the endoplamsic reticulum and activates phospholipid metabolism

BUSSOLINO DF; GUIDO ME; GIL GA; BORIOLI GA; RENNER ML; GRABOIS VR; CONDE CB; CAPUTTO BL

FEDERATION AMER SOC EXP BIOL

Lugar: Bethesda; Año: 2001 vol. 15 p. 556 - 556

font face="Times"> c-Fos, a transcription factor that constitutes DNA-binding AP-1 complexes, regulates gene expression that promotes long-lasting cellular changes. We show that, in addition to its transcription factor activity, c-Fos regulates the metabolism of phospholipids cytoplasmically by an AP-1-independent activity. Two waves of c-Fos expression that promote subsequent waves of stimulation of 32P-orthophosphate incorporation into phospholipids are evidenced in quiescent cultured fibroblasts induced to re-enter the cell cycle. The first wave of c-Fos expression peaks at 7.5 min and returns to control levels by 15 min. The second wave starts by 30 min and remains elevated at 120 min. In the first wave, the lipids that incorporate