Phospholipase activity is modulated by c-Fos through substrate expansion and hyperpolarization.

BORIOLI BA, CAPUTTO BL, MAGGIO B

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2004 vol. 570 p. 82 - 82

font size="1" face="AdvPSTim-B"> c-Fos, a component of AP-1 transcription factors, has been shown to have marked amphitropic properties and to regulate phospholipase activity against lipid monolayers. In agreement with its high surface activity, it has also been found to associate to membranes of the endoplasmic reticulum and to activate phospholipid metabolism in vivo. All these findings point to an involvement of this oncoprotein within a membrane environment. We have previously shown that c-Fos modulates in different manners the activity of phospholipase A2 and