Mechanistic insights into the non-genomic regulation of phospholipid synthesis enzymes

CARDOZO GIZZI AM; CAPUTTO BL

JOHN WILEY & SONS INC

Lugar: New York; Año: 2013

ipid synthesis is a complex process regulated at multiple levels. Here, we will discuss non-genomic regulatory mechanisms, particularly the activation and/or recruitment of key enzymes to membranes. The phospholipid synthesis enzymes Lipin and CCT1 are taken as examples of these kind of mechanisms, that are mediated by posttranslational modifications or by an intrinsic property of the enzyme that senses lipid composition. In addition, special emphasis will be put on another relevant non genomic lipid synthesis regulation mechanism that is dependent on c-Fos, a protein that has deserved less attention so far. This latter regulatory mechanism is emerging as an important determinant for processes that require high rates of lipid synthesis such as those of growth and proliferation.