Growth of Peripheral and Central Nervous System tumors is supported by cytoplasmic c-Fos in humans and mice.

SILVESTRE DC; GIL GA; TOMASINI N; BUSSOLINO DF; CAPUTTO BL

PUBLIC LIBRARY SCIENCE

Lugar: New York; Año: 2010 vol. 5 p. 9544 - 9544

AbstractBackground: We have previously shown that the transcription factor c-Fos is also capable of associating to endoplasmic reticulum membranes (ER) and activating phospholipid synthesis. Herein we examined phospholipid synthesis status in brain tumors from human patients and from NPcis mice, an animal model of the human disease Neurofibromatosis Type 1 (NF1).Principal Findings: In human samples, c-Fos expression was at the limit of detection in non-pathological specimens, but was abundantly expressed associated to ER membranes in tumor cells. This was also observed in CNS of adult tumor- bearing NPcis mice but not in NPcis fos(2/2) KO mice. A glioblastoma multiforme and a malignant PNS tumor from a NF1 patient (MPNST) showed a 2- and 4- fold c-Fos-dependent phospholipid synthesis activation, respectively. MPNST samples also showed increased cell proliferation rates and abundant c-Fos expression.Conclusions: Results highlight a role of cytoplasmic c-Fos as an