Autor/es:
GALIANO, M. R.; BOSC C.; ANDRIEUX A., JOB, D. & HALLAK, M.
Resumen:
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Many cell types contain subpopulations of microtubules
that resist depolymerizing conditions, such as exposure
to cold or to the drug nocodazole. This stabilization is
due mainly to polymer association with STOP proteins. In
mouse, neurons express two major variants of these
proteins, N-STOP and E-STOP (120 kDa and 79 kDa,
respectively), whereas fibroblasts express F-STOP (42
kDa) and two minor variants of 48 and 89 kDa. N- and
E-STOP induce microtubule resistance to both cold and
nocodazole exposure, whereas F-STOP confers microtubule
stability only to the cold. Here, we investigated the
expression of STOP proteins in oligodendrocytes and
astrocytes in culture. W