TREATMENT WITH A HYBRID BETWEEN THE SYNAPSIN ABC DOMAINS AND THE B SUBUNIT OF E. COLI HEAT-LABILE TOXIN REDUCES FREQUENCY OF PROINFLAMMATORY CELLS AND CYTOKINES IN CENTRAL NERVOUS SYSTEM OF RATS WITH EAE

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2014 vol. 277 p. 217 - 217

ultiple sclerosis and its animal model, EAE, are crucially dependent on the invasion of activated autoreactive lymphocytes and blood macrophages into the central nervous system. Proinflammatory mononuclear cells and activated local microglia mediate inflammation, demyelination and axonal damage at the target organ. Previously, we observed that the administration of a hybrid between the synapsin ABC domains and the B subunit of E. coli heat labile-enterotoxin (LTBABC) to rats with EAE ameliorated disease by modulating the peripheral Th1 response to myelin basic protein (MBP). In the present study, we investigated the effect of LTBABC administration on proinflammatory cell frequency into the central nervous system of rats with EAE. Treatment with the hybrid in the inductive phase of EAE attenuated disease severity and diminished histological inflammatory infiltrates and demyelination in the spinal cord of rats with acute EAE. Lower frequencies of infiltrating and local macrophages as we