Artículos
Título:
Ability of Blood Group A-Active Glycosphingolipids to Act as Escherichia coli Heat-Labile Enterotoxin Receptors in HT-29 Cells
Autor/es:
GALVÁN ESTELA M.; DIEMA CALUDIO D.; ROTH GERMÁN A; MONFERRAN CLARA G.
Editorial:
The Infectious Diseases Society of America
Referencias:
Año: 2004 vol. 189 p. 1556 - 1556
Resumen:
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We examined the ability of blood group A?active glycoconjugates to act as receptors for Escherichia coli heatlabile
type I enterotoxin (LT-I) in HT-29 cells. These cells contained ~4 times more specific binding sites for
LT-I than for cholera toxin (CT). Binding of LT-I could not be blocked by the B subunit of CT (CT-B),
indicating the existence of LT-I receptors in addition to the glycosphingolipid GM1. LT-I was able to increase
levels of cyclic adenosine monophosphate (AMP), even in the presence of CT-B. Helix pomatia and anti?blood
group A antibody caused a dose-dependent inhibit