Inhibitory role of diazepan in autoimmune inflammation in rats with experimental autoimmune encephalomyelitis

BIBOLINI M J, CHANADAY NL, DEGANO AL, MONFERRAN CG, ROTH GA

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2011 vol. 199 p. 421 - 421

span style="FONT-FAMILY: Arial; FONT-SIZE: 11pt; mso-fareast-font-family: "Times New Roman"; mso-ansi-language: EN-US; mso-fareast-language: ES; mso-bidi-language: AR-SA" lang="en">Glutamate and GABA are the main excitatory and inhibitory neurotransmitters in the central nervous system and both may be involved in the neuronal dysfunction in neurodegenerative conditions. We have recently found that glutamate release was decreased in isolated synaptosomes from the rat cerebral cortex during the development of experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis. In contrast to control animals where GABA