Surface behavior and peptide ?lipid interactions of the cyclic neuropeptide melanin concentrating hormone (MCH).

VARAS MARIANA; SANCHEZ JULIETA; SANCHEZ MARIELA; RUBIALES DE BARIOGLIO, SUSANA ELIZABETH; PERILO MARIA

J Phys Chem B

ACS Publications

Año: 2009 vol. 112 p. 7330 - 7330

1520-6106

font face="Times-Roman" size="2"> The kinetics and the thermodynamics of melanin concentrating hormone (MCH) adsorption, penetration, and mixing with membrane components are reported. MCH behaved as a surface active peptide, forming stable monolayers at a lipid-free air-water interface, with an equilibrium spreading pressure, a collapse pressure, and a minimal molecular area of 11 mN/m, 13 mN/m, and 140 Å2, respectively. Additional peptide interfacial stabilization was achieved in the presence of lipids, as evidenced by the expansion observed at