Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory

VALERIA PAOLA CARLINI; DANIELE G MACHADO; FLORENCIA BUTELER; MARISA GHERSI; MARINA F PONZIO; ANA CAROLINA MARTINI; HELGI B SCHIöTH; MARTA FIOL DE CUNEO; ANA LúCIA S RODRIGUES; RUBIALES SUSANA DE BARIOGLIO

ELSEVIER SCIENCE INC

Año: 2012

font size="3" face="Cambria"> This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfactory bulbectomy (OB), an established animal model of depression. The reduction in the immobility time in the TST was the parameter used to assess antidepressant-like effect of Ghr. The depressive-like behavior in olfactory bulbectomized mice was inferred through the increase in the immobility time in the TST and the hyperlocomotor activity in the open-field test. Ghr produced antidepressant-like effect in TST (0.3 nmol/ìl, i.c.v.), and reversed OB-induced depressivelike behavior. In conclusion, these results provide clear evidence that an acute administration of ghrelin produce antidepressant-like