The intra-hippocampal leucine administration impairs memory consolidation and LTP generation in rats

VIVIANE GLASER; VALERIA P. CARLINI; LAURA GABACH,; MARISA GHERSI,; SUSANA RUBIALES DE BARIOGLIO,; OSCAR A. RAMIREZ ; MARIELA PEREZ; ALEXANDRA LATINI

SPRINGER/PLENUM PUBLISHERS

Año: 2010 vol. 30 p. 1067 - 1067

font face="Times New Roman"> Leucine (LEU) accumulates in fluids and tissues of patients affected by maple syrup urine disease (MSUD), an inherited metabolic disorder, predominantly characterized by neurological dysfunction. Although, a variable degree of cognition/psychomotor delay/mental retardation is found in a considerable number of MSUD individuals, the mechanisms underlying the neuropathology of these alterations are still not defined. Therefore, the aim of this study was to investigate the effect of acute intra-hippocampal LEU administration in the step-down test in rats. In addition, the LEU effects on the electrophysiological parameter, long-term potentiation (LTP) generation, and on the activities of the respiratory chain were also investigated. Male Wistar rats were bila