Nitric oxide synthase and Long Term Potentiation (LTP) participate in the Ghr induced hippocampal-dependent memory facilitation

VALERIA P. CARLINI; MARIELA F. PEREZ; ESTELA SALDE; HELGI B. SCHIÖTH; OSCAR A RAMIREZ; RUBIALES DE BARIOGLIO, SUSANA ELIZABETH

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2010 vol. 101 p. 117 - 117

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 200%; TEXT-ALIGN: justify; mso-layout-grid-align: none">Although the hypothalamus has been long considered the main ghrelin (Ghr) target organ mediating orexigenic effects, recently it has been shown that in-vivo Ghr hippocampus administration improves learning and memory in the inhibitory avoidance paradigm. However, the possible mechanisms underlying this memory facilitation effect have not been clarified. Given that the biochemical memory cascade into the hippocampus involves nitric oxide (NO) synthesis via NO synthase (NOS) activation, we investigated 1) if Ghr