HIPPOCAMPAL EFFECTS OF NEURONOSTATIN ON MEMORY,

CARLINI VP; GHERSI M,; GABACH L,; SCHIÖTH HB; PÉREZ MF; RAMIREZ OA; FIOL DE CUNEO M; RUBIALES SUSANA

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2011 vol. 197 p. 145 - 145

nbsp;13-amino acid peptide named neuronostatin (NST) encoded in the somatostatin pro-hormone has been recently reported. It is produced throughout the body, particularly in brain areas that have significant actions over the metabolic and autonomic regulation. The present study was performed in order to elucidate the functional role of NST on memory, anxiety-like behavior and food intake and the hippocampal participation in these effects. When the peptide was intra-hippocampally administered at 3.0 nmol/ìl, it impaired memory retention in both, object recognition and step-down test. Also, this dose blocked the hippocampal long-term potentiation (LTP) generation. When NST was intra-hippocampally administered at 0.3 nmol/ìl and 3.0 nmol/ìl, anxiolytic effects were observed. Also, the administration in the third ventricle at the higher dose (3.0 nmol/ìl) induced similar effects, and both doses reduced food intake. The main result of the present study is the relevance of the hippocampal fo