Ghrelin inhibited serotonin release from hippocampal slices.

GHERSI MARISA SOLEDAD; CASAS SEBASTIAN M; ESCUDERO CARLA; CARLINI VALERIA ; BUTELER FLORENCIA; CABRERA RICARDO J; SCHIÖTH HELGI B.; RUBIALES DE BARIOGLIO SUSANA R

ELSEVIER SCIENCE INC

Año: 2011 vol. 32 p. 2367 - 2367

p>Ghrelin (Ghr) is a peptide produced peripherally and centrally. It participates in themodulation of different biological processes. In our laboratory we have shown that a) Ghradministration, either intracerebroventricular or directly into the hippocampus enhanced memoryconsolidation in a step down test in rats b) the effect of Ghr upon memory decreases in animalspretreated with a 5-HT reuptake inhibitor, Fluoxetine, suggesting that Ghr effects in the hippocampus could be related to the availability of 5-HT. It has been demonstrated that Ghr inhibits 5-HT release from rat hypothalamic synaptosomes. Taking in mint these evidences, we studied the release of radioactive 5-HT to the superfusion medium from hippocampal slices treated with two doses of Ghr (0.3 and 3 nmol/ul) Ghr inhibited significantly the 5-HT release in relation to those superfused with artificial cerebrospinal fluid (ACSF) (H =9.48, df= 2, p ¡Ü 0.05). In another set of experiments, Ghr was infus