DECREASED MEMORY FOR NOVEL OBJECT RECOGNITION IN

V. P. CARLINI; A. C. MARTINI; H SCHIOT; R. D. RUIZ; M. FIOL DE CUNEO; SUSANA ELIZABETH RUBIALES

Elsevier

Año: 2008 vol. 153 p. 929 - 929

b> Abstract?It has been demonstrated, in normal and aged rats and mice, that acute i.c.v. ghrelin (Ghr) administration increases memory retention. In order to evaluate if this treatment, restores memory retention in animals exhibiting impaired memory, in the present work we selected a chronic food restriction mouse model (since undernutrition prejudices higher nervous functions). We employed adult female mice with 28 days of 50% food restriction and evaluated: a) behavioral performance using novel object recognition test for memory, and plus maze for anxiety-like behavior, b) some morphometric parameters as body and hepatic weights and c) plasma Ghr levels. The animals with 50% food res