Ghrelin increases memory consolidation through hippocampal mechanisms dependent ...

GHERSHI M; GABACH L,; PÉREZ MF; VILCAES ALEJANDRO; SCHIÖTH HB; RUBIALES DE BARIOGLIO SUSANA R

PSYCHOPHARMACOLOGY

SPRINGER

Lugar: Berlin; Año: 2015 vol. 232 p. 1845 - 1845

0033-3158

bstract RATIONALE: Ghrelin (Ghr) is a peptide that participates in the modulation of several biological processes. Ghr administration into the hippocampus improves learning and memory in different memory tests. However, the possible mechanisms underlying this effect on memory have not yet been clarified. OBJECTIVE: The purpose of the present work is to add new insights about the mechanisms by which Ghr modulates long-term memory consolidation in the hippocampus. We examined Ghr effects upon processes related to increased synaptic efficacy as presynaptic glutamate release and changes in the expression of the NR2B-subunits containing n-methyl-d-aspartate receptors (NMDAR), which are critical for LTP induction. We also attempted to determine the temporal window in which Ghr administration induces memory facilitation and if the described effects depend on GHS-R1a stimulation. RESULTS: The present research demonstrated that Ghr increased glutamate release from hippocampal synap