RUBIALES SUSANA ELIZABETH
Congresos y reuniones científicas
Título:
EFFECTS OF HEXARELIN UPON MICE MEMORY ACQUISITION
Autor/es:
CARLINI V,; MARTINI AC; VINCENTI LM,; LUQUE EM,; PUECHAGUT P; RUIZ RD,; RUBIALES DE BARIOGLIO S; FIOL DE CUNEO M
Reunión:
Congreso; XVII Jornada de la Sociedad de Biología de Córdoba.; 2009
Resumen:
The demonstrated stimulating effects of ghrelin (Ghr) upon memory are capable to revert the deleterious effects provoked by chronic food restriction. The objectives of the present study were to evaluate the effects of a ghrelin analogue employed in human therapy, hexarelin (HEX), upon mice memory acquisiton, employing an novel object recognition test at 1h and 24 h, in two designs: A) HEX administration (100 ó 200 ug/kg/día, sc) to adult mice for 28 days and B) HEX administration (200 ug/kg/día, sc) to pregnant females during different periods, evaluating memory acquisition in their litter at adulthood. In A, HEX diminished memory vs control group (C) in females with both doses assayed (% of time exploring novel object: C 1h: 68.5±2.3, n=14; HEX100 24h: 36.2±6.9, n=7; HEX200 1h: 39.2±4.7, n=8; HEX200 24h: 37.6±3.2, n=8, p<0.05) while in males, only with the mayor one (C 24h: 62.4±2.2, n=11 y HEX200 24h: 48.8±4.5, n=7, p< 0.05). In B, memory was altered (specially in females) only when pregnant females were treated for the whole pregnancy or during the first third. In contrast, this last treatment accelerated the neurobehavioral development (negative geotaxis, surface righting reflex and cliff avoidance, at 8 to 10 posnatal days). These discrepancies could be attributed to differential effects of HEX upon different central nervous system structures
