Effects of cholinesterase inhibitors and clonidine coadministration on rat cortex neurotransmitters in vivo.

CUADRA, G. AND GIACOBINI, E.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

American Society for Pharmacology and Experimental Therapeutics

Lugar: United States; Año: 1995 vol. 275 p. 228 - 228

0022-3565

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify; mso-layout-grid-align: none">In previous investigations, we have demonstrated that choIinesterase inhibitors such as physostigmine (PHY) and heptylphysostigmine (HEP) elicit a significant and simultaneous increase in acetyicholine (ACh) and norepinephrine (NE) levels in the rat cortex. This effect is enhanced by idazoxan, a selective a!pha-2 antagonist. These data suggest that a combination of cholinergic and adrenergic drug may improve the pharmacological effect of the cholinesterase inhibitor on cortical neurotransmitters such as ACh-NE. In order to obtain additional information on cortical cortical neurotransmitter interaction, we tested, in the cerebral cortex of the rat, the effect of PHY and HEP in animals pretreat