Coadministration of cholinesterase inhibitors and idazoxan: Effects on neurotransmitters in rat cortex in vivo.

CUADRA, G. AND GIACOBINI, E.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

American Society for Pharmacology and Experimental Therapeutics

Lugar: United States; Año: 1995 vol. 273 p. 230 - 230

0022-3565

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify; mso-pagination: widow-orphan; mso-layout-grid-align: none">Based on previous results indicating that cholinesterase inhibitors (ChEl) elicit a significant and simultaneous increase in acetylcholine (ACh) and norepinephrine (NE) ievels, we studied whether the NE elevation could down-regulate ACh levels and possibly decrease the therapeutical effect of these drugs. A modified microdialysis technique without ChEI in the probe was used to study the putative interaction of these neurotransmitters in cerebral cortex of freely mo