Effect of nicotine on levels of acetylcholine and biogenic amines in rat cortex.

SUMMERS, K.L., CUADRA, G.R., NARITOKU, D. AND GIACOBINI, E.

DRUG DEVELOPMENT RESEARCH

Wiley-Liss, Inc.

Lugar: United States; Año: 1994 vol. 31 p. 108 - 108

0272-4391

p class="MsoNormal" style="MARGIN: 0cm -0.05pt 0pt 0cm; TEXT-ALIGN: justify">Transcortical dialysis was employed to investigate the effects of systemic nicotine (3.6 µmol/kg, sc) administration on cortical extracellular levels of acetylcholine (ACh), norepineph­rine (NE), dopamine (DA), and serotonin (5-HT). Systemic administration of [-]-nicotine produced a 106% increase of cortical ACh release over basal levels that persisted for approximately 2 h. Concurrently, NE levels were increased 86% over basal values for 60