Perinatal protein malnutrition enhances rewarding cocaine properties in adult rats.

VALDOMERO, A., BUSSOLINO, D., ORSINGHER, O., CUADRA, G.

NEUROSCIENCE

Elsevier

Lugar: Oslo, Norway; Año: 2006 vol. 137 p. 221 - 221

0306-4522

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none">The rewarding properties of cocaine were assessed in adult rats submitted to a protein malnutrition schedule from the 14th day of gestation up to 40 days of age (deprived rats), as compared with well-nourished animals (control rats) using the conditioned place preference paradigm. Dose-response curves to cocaine (3, 5, 10, 15, 30, 45 or 60 mg/kg i.p.) revealed in deprived rats a conditioning effect with doses of 5 and 10 mg/kg; doses of 15 and 30 mg/kg did not show any conditioning place preference and doses of 45 and 60 mg/kg revealed a significant aversive effect. In control rats, cocaine elicited place preference with doses of 10, 15 and 30 mg/kg, whereas 4