Aversive stimulation of the inferior colliculus changes dopamine and serotonin extracellular levels in the frontal cortex: Modulation by the basolateral nucleus of amygdala.

MACEDO, C. E., CUADRA, G., MOLINA, V., BRANDAO, M.L.

SYNAPSE

Wiley-Liss

Lugar: California, USA; Año: 2005 vol. 55 p. 58 - 58

0887-4476

span lang="en" style="FONT-SIZE: 11pt; LINE-HEIGHT: 150%; FONT-FAMILY: Arial; mso-fareast-font-family: "Times New Roman"; mso-ansi-language: EN-US; mso-fareast-language: PT-BR; mso-bidi-language: AR-SA">We have shown that stimulation of the neural substrates in the inferior colliculus (IC) causes significant increase in the extracellular levels of dopamine (DA) in frontal cortex (FC). Also, it has been reported that the basolateral complex of the amygdala (BLA) serves as a filter for unconditioned and conditioned aversive information that ascend to higher structures from the brainstem. Linking these two kinds of information this work examines whether inactivation of BLA interferes with the activation of cortical dopaminergic outputs produced by aversive stimulation of the IC. To this end, rats were implanted with an electrode in the IC for the determination of the threshold of escape responses. Each rat also bore a cannula implanted in the BLA for injections of lidocaine (10