Behavioral reactivity following 5 MeODMT administration in 5,7 DHT pretreated killer rats.

CUADRA, G.R. AND MOLINA, V.A.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Pergamon Press

Lugar: United States; Año: 1990 vol. 36 p. 287 - 287

0091-3057

span lang="en" style="FONT-SIZE: 10pt; FONT-FAMILY: Arial; mso-fareast-font-family: "Times New Roman"; mso-ansi-language: EN-US; mso-fareast-language: ES-MX; mso-bidi-language: AR-SA">Grouped, nonkiller and killer animals were centrally injected either with vehicle or with 5,7-dihydroxytryptamine. After a period of 7-10 days, forepaw treading and hindlimb abduction were induced by 5-MeODMT administration in all sham and lesioned rats. As expected, behavioral supersensitivity was observed in grouped and nonkiller lesioned rats. A reduced increase in 5-MeODMT-induced behaviors was obtained in killer lesioned animals. 5-HT uptake studies showed a comparable reduction of 5-HT uptake within all the lesioned rats. This evidence suggests an altered capacity to promote adaptive changes on 5-HT sites in killer rats following the destruction of central serotonergic fibers.