CUADRA GABRIEL RICARDO
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Título:
Perinatal protein malnutrition enhances locomotor?s morphine effects in adult rats. Sensitization and cross-sensitization study.
Autor/es:
VELAZQUEZ E.E, VALDOMERO A., ORSINGHER O.A. Y CUADRA G.R.
Lugar:
Córdoba
Reunión:
Congreso; XXXVIII Reunión Anual de S.A.F.E. (Asociación Argentina de Farmacología Experimental); 2006
Institución organizadora:
Asociación Argentina de Farmacología Experimental
Resumen:
The influence of neuronal alterations induced by early undernutrition on the locomotor effect of morphine was evaluated in adult rats submitted to a protein malnutrition schedule at perinatal age. To assess the sensitization phenomenon induced by repeated morphine administration, different groups of control (C) and deprived (D) received five intermittent injections (every 48 hours) of morphine (7.5 or 10 mg/kg, i.p.) or saline (1ml/kg, i.p.). Following each administration behavioral parameters were assessed in a locomotor activity cage. Our data revealed a shift to the left in the activity curves of the D rats compare to controls. Thus, D animals showed a clear behavioral sensitization to the lower dose of morphine, whereas this phenomenon was only observed in C rats for the higher dose used. Moreover, only D animals expressed cross-sensitization to locomotor activity after a challenge with cocaine (10 mg/kg, i.p., 48 hours after the final morphine administration) in morphine pre-exposed animals (lower dose). These results suggest that D rats had a lower threshold for developing a progressive behavioral sensitization to morphine as well as cross-sensitization to cocaine.
