CUADRA GABRIEL RICARDO
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Título:
Perinatal protein malnutrition enhances rewarding properties of morphine in adult rats.
Autor/es:
VALDOMERO A., VELAZQUEZ E., DE OLMO S., ORSINGHER O.A. Y CUADRA G.R.
Lugar:
Mar del Plata
Reunión:
Congreso; XXXVII Reunión Anual de S.A.F.E. (Asociación Argentina de Farmacología Experimental); 2005
Institución organizadora:
Asociación Argentina de Farmacología Experimental
Resumen:
The rewarding properties of morphine were assessed in adult rats submitted to a protein malnutrition schedule at perinatal age (Drats), as compared with well-nourished animals (C-rats) using the Conditioned Place Preference (CPP) paradigm. Dose-response curves to morphine (0.75, 1.5, 3, 6 and 12 mg/kg i.p.) revealed in D-rats a conditioning effect with doses of 1.5 and 3 mg/kg whereas doses of 6 and 12 mg/kg did not show any conditioning place preference. In C-rats, morphine elicited place preference with doses of 3 and 6 mg/kg, whereas 12 mg/kg did not show conditioning effect. Furthermore, when the animals where pretreated twice a day for three days with increasing doses of morphine (5, 10 and 20 mg/ kg, s.c.) only D-rats showed sensitization to the conditioning effect of a low dosage of morphine (0.75 mg/kg i.p.). Related to the higher rewarding effects, sensitized D-rats showed a selective and significant increase in FosB expression in nucleus accumbens (core and shell), basolateral amygdala and medial prefrontal cortex, brain areas related to the rewarding neuronal circuits. These results suggest that a deficient nutritional status during early life may induce in adult subjects an increased responsiveness to behavioral effects of morphine and/or enhanced reinforcement during abstinence.
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